On the other hand, the adrenal medulla contains chromaffin cells, which are responsible for the biosynthesis and secretion of the catecholamines epinephrine and norepinephrine. Indeed, the adrenal cortex consists of the zona glomerulosa, the zona fasciculata, and the zona reticularis, which respectively produce mineralocorticoids (aldosterone), glucocorticoids (cortisol in man and corticosterone in rodents), and adrenal androgens ( 4, 5). In the midst of the 19th century, newly emerged histochemical techniques showed that the adrenal consists of a cortex and medulla and have divergent albeit interdependent cellular and functional properties. The latter performed a series of bilateral adrenalectomies in dogs, demonstrating that these endocrine glands were necessary for life ( 2, 3). The adrenal gland was first described by Eustachius in 1563 and its importance was later recognized by the work of Thomas Addison in 1855 and Brown-Sequard in 1856 ( 1- 3).
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